Effects of cerium dioxide nanoparticles in Oncorhynchus mykiss gills after an acute exposure: assessment of oxidative stress, genotoxicity and histological alterations

Abstract

Event Abstract Back to Event Effects of cerium dioxide nanoparticles in Oncorhynchus mykiss gills after an acute exposure: assessment of oxidative stress, genotoxicity and histological alterations Inês Ribeiro1, Sara C. Antunes1, 2, Ana C. Nunes1 and Alberto T. Correia1, 2* 1 Universidade Fernando Pessoa (UFP), Portugal 2 Centro Interdisciplinar de Investigação Marinha e Ambiental (CIIMAR/CIMAR), Portugal Data about the toxicological effects of cerium dioxide nanoparticles (CeO2 NP) in fish are scarce. This work aimed to assess the CeO2 NP possible deleterious effects on the gills of Oncorhynchus mykiss. A semi-continuous acute test was conducted to expose the rainbow trout to a freshwater control, 0.25, 2.50 and 25.00 mg/L CeO2 NPs for up to 96 hours. Gills pathological index showed a dose-effect relationship for the individuals exposed to CeO2. Gills showed aneurisms, epithelial lifting and hyperplasia. Furthermore exposure to CeO2 NPs caused statistical differences in some biomarkers determinations, namely a significant increase in the catalase activity and genotoxicity the higher concentrations. No significant changes were however observed in thiobarbituric acid reactive substances content, Na+-K+ ATPase and glutathione s-transferase activities. This study suggests that CeO2 nanoparticles are toxic compounds that can lead to histological, biochemical and genotoxic alterations. Keywords: Nanoparticles, biomarkers, Histology, Oxidative Stress, Genotoxicity Conference: XV European Congress of Ichthyology, Porto, Portugal, 7 Sep - 11 Sep, 2015. Presentation Type: Poster Presentation Topic: Physiology, Behavior and Toxicology Citation: Ribeiro I, Antunes SC, Nunes AC and Correia AT (2015). Effects of cerium dioxide nanoparticles in Oncorhynchus mykiss gills after an acute exposure: assessment of oxidative stress, genotoxicity and histological alterations. Front. Mar. Sci. Conference Abstract: XV European Congress of Ichthyology. doi: 10.3389/conf.FMARS.2015.03.00209 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 07 Dec 2015; Published Online: 07 Dec 2015. * Correspondence: Prof. Alberto T Correia, Centro Interdisciplinar de Investigação Marinha e Ambiental (CIIMAR/CIMAR), Porto, Portugal, atcorreia.ciimar@gmail.com Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract Supplemental Data The Authors in Frontiers Inês Ribeiro Sara C Antunes Ana C Nunes Alberto T Correia Google Inês Ribeiro Sara C Antunes Ana C Nunes Alberto T Correia Google Scholar Inês Ribeiro Sara C Antunes Ana C Nunes Alberto T Correia PubMed Inês Ribeiro Sara C Antunes Ana C Nunes Alberto T Correia Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.