Effects of cerebral perfusion pressure on acute cerebral ischemia after traumatic brain injury

Abstract

Objective To investigate the effects of cerebral perfusion pressure (CPP) on acute cerebral ischemia after traumatic brain injury. Methods Sixty rabbits were randomly divided into the control group, the high CPP group (90-110 mm Hg), the middle CPP group (70-80 mm Hg), the low CPP group (50-60 mm Hg), the lower CPP group (35-45 mm Hg). By using the Feeney's Method of falling the body to bump the shot, a model of acute focal contusion and laceration of brain was established. By using medicine, the blood pressue was adjusted and controlled to make the CPP in the design request 80 min after the injury. Cerebral blood flow (CBF) and cerebral peffusion pressure (CPP) were measured. The changes in water content in brain and ultra-microstructures in nervous tissue induced by CPP after traumatic brain injury were observed. Results The water content and natrium in brain of experimental group were significantly higher than in control group (P 0.05). The changes in water content in brain and ultra-microstructures in nervous tissue in the low CPP group and the lower group were more significant than the control group (P<0.01). Conclusion To improve cerebral circulation availably is the important link to prevent the acute cerebral ischemia making the irreversible damage of brain after traumatic brain injury. Key words: Traumatic brain injured; Cerebral perfusion pressure; Cerebral ischemia