Abstract

Interruption of the blood supply to the brain results in elevation of arterial blood pressure [1]. Many experiments have been performed to understand the central neural mechanisms responsible for this phenomenon but is not known whether the neuronal networks involved in central cardiovascular control respond to physiological and pharmacological stimuli after an ischemic insult as in normal animals. In the present study the response of central cardiovascular system to the hypotensive drugs clonidine and neuropeptide Y (NPY) was evaluated in ischemic rats at various time intervals after reperfusion.

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