Abstract
A test procedure is described for use in quantitating the effects of drugs which stimulate or depress central nervous system function. Motor activity of rats is measured by photoelectric cells while the rats are confined in a small plastic chamber. The chamber is designed to permit the rats to exhibit “up and down” exploratory movements but not movement from place to place, i.e., locomotor activity. Drugs tested include caffeine, d-amphetamine, phenmetrazine, methylphenidate, pipradrol, tranylcypromine, chlorpromazine, prochlorperazine, trifluoperazine, and chlordiazepoxide. Advantages of the test include a high degree of reproducibility, selectivity, and sensitivity. Two of the drugs mentioned, namely caffeine and tranylcypromine, were especially potent by this test, in spite of the fact that they are essentially inactive by the conventional photoelectric cell locomotor activity test.
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