Year-end Sale % OFF 
Abstract
Aims: This study aims to determine at the effect of Centella asiatica L. (CA) on Neurotrophin-3 (NT-3) brain level and Cyclin-dependent kinase inhibitor 2A (CDKN2A) brain level of rats aged 12, 24 and 36 weeks.
 Study Design: Experimental studies used rats aged 12, 24, and 36 months which were treated with CA extract 300 mg/BW was administered orally for 29 days in a row as described in previous study. In addition, untreated rats aged 12, 24, and 36 months were used as negative controls.
 Place and Duration of Study: Department of Biochemistry and Biology Molecular, Faculty of Medicine, Universitas Indonesia.
 Methodology: NT-3 and CDKN2A brain levels were measured using the ELISA method.
 Results: The results showed a significant decrease in NT-3 levels in rats aged 36 weeks that were given CA compared to control rats (Sidak multiple comparison test; P = .0493). In addition, the CDKN2A levels of CA-treated rats aged 36 weeks that were compared to control rats (Sidak multiple comparison test, P = .0041).
 Conclusion: This study proved that giving CA 300mg/kgBW for 29 days in adult rats aged 36 weeks has not been able to prevent aging in terms of NT-3 and CDKN2A proteins.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
