Abstract
Background: It has been reported that cellphone radiation (CR) is related to higher risk of many health problems, but whether CR can impair the expression of rate-limiting enzymes of testosterone synthesis has seldom been studied. Objective: To evaluate the effects of CR on the expression of steroidogenic acute regulatory protein (StAR) in the testes tissue and the sperm quality of adult male mice. Methods: Forty 3-month-old male mice, 22 - 26 g, were randomly assigned into four equal groups (n = 10 per group): the control group and three CR exposure groups including 8-hour group, 16-hour group and 24-hour group. Each mouse received different dosages of CR exposure for seven consecutive weeks. Semen in the epididymis, intratesticular testosterone (ITT) concentrations, and the expression of StAR were measured at the end of experiment. Results: The sperm number and motility, and the ITT concentrations in 24-h group were significant lower than those in the control group (P 0.05). Similarly, only the expression of StAR in the 24-h group was significantly decreased after the exposure of CR (P 0.05). Conclusions: High dose exposure of CR can reduce the expression of StAR and ITT concentration, and then suppress the serum quality.
Highlights
Nowadays most men own cellphones, and this phenomenon arouse the concern over the potential effects of cellphone radiation (CR) exposure on human health, including human fertility
It has been reported that cellphone radiation (CR) is related to higher risk of many health problems, but whether CR can impair the expression of rate-limiting enzymes of testosterone synthesis has seldom been studied
Results indicated that there was a significant decrease in sperm number and motility in the 24-h group compared with the control group (Figure 1)
Summary
Nowadays most men own cellphones, and this phenomenon arouse the concern over the potential effects of cellphone radiation (CR) exposure on human health, including human fertility. The aim of this study was to assess whether CR could affect the level of ITT and decrease the sperm quality of mice. We tested the expression of one rate-limiting enzymes of testosterone synthesis, steroidogenic acute regulatory protein (StAR), to elucidate the mechanism of CR action in this process. It has been reported that cellphone radiation (CR) is related to higher risk of many health problems, but whether CR can impair the expression of rate-limiting enzymes of testosterone synthesis has seldom been studied. Objective: To evaluate the effects of CR on the expression of steroidogenic acute regulatory protein (StAR) in the testes tissue and the sperm quality of adult male mice. Conclusions: High dose exposure of CR can reduce the expression of StAR and ITT concentration, and suppress the serum quality
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