Abstract
In 10 patients with bronchial asthma but normal ventilatory function, celiprolol, a cardioselective β-adrenoreceptor antagonist, did not significantly affect forced expiratory volume in 1 second (FEV 1) or airways resistance (Raw). In contrast, metoprolol substantially reduced FEV 1 and increased Raw. In addition, compared with metoprolol, celiprolol induced a greater recovery of FEV 1 and Raw after methacholine-induced bronchoconstriction.
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