Abstract
Nanotechnology is widely applied in biomedicine and pharmacy. It is necessary to systematic analysis the potential hazardous of QDs s to ensure their safe usage. Here, we analyzed the in vivo oxidative stress of CdSe/ZnS-QD525 at different time via intraperitoneal injection of CdSe/ZnS-QD525 in male KM mice. The results showed that in 30 nmol/kg dose group, the GSH levels of liver and kidneys were significantly decreased at day 11 (p < 0.05), while the GSH levels in liver on day 33 and in kidneys on day 22 were significantly increased (p < 0.01). The SOD activity in liver was significantly reduced (p < 0.01) of the 30 nmol/kg dose group on day 22, and the SOD activity in liver of low, middle and high dose groups treated for 33 days was significantly increased (p < 0.01). The CAT activity in liver of 30 nmol/kg and 150 nmol/kg dose groups on day 33 was significantly lower (p < 0.05) than the control group, the CAT activity was significantly increased (p < 0.05) of 30 nmol/kg dose group in kidneys. Therefore, this study indicated that CdSe/ZnS-QD525 induced oxidative damage, and caused related toxicity, which provided valuable information in evaluating the biological safety of QDs.
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