Abstract
Some properties of a (Na + + Mg 2+)-dependent ADP-ATP exchange reaction catalyzed by Nal-treated rat brain microsomes have been investigaged. The (Na + + Mg 2+)-activated exchange exhibited an absolute requirement for Na +, was inhibited by ouabain and stimulated 2–3-fold by oligomycin. The optimum MgCl 2 concentration for the (Na + + Mg 2+)-activated exchange was 1.0 mM, but in the presence of oligomycin 3.0 mM MgCl 2 was required for optimum activity. The exchange reaction exhibited a complex multiphasic response to increasing concentration of Na +, with activity increasing up to 200 mM NaCl.
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