Abstract
In the submandibular gland of intact mice, there is a sex diffecence in cytosol androgen receptor level, being higher in females. The exchange assay using mersalyl and monothio-glycerol revealed that cytosol androgen receptor in both sexes is mostly unoccupied. To understand the action of androgen via androgen receptor in the submandibular gland, cytosol androgen receptor level and androgen-dependent N-tosyl-L-arginine methyl ester esterase (TAMEase) activity, being higher in males were determined under endocrine manipulations. In males, castration elevated unoccupied cytosol androgen receptor level and reduced the TAMEase activity. Injection of testosterone decreased unoccupied cytosol androgen receptor level and increased TAMEase activity in females, whereas injection of estradiol exerted no effects on cytosol androgen receptor level and TAMEase activity in males.
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