Abstract
The effect of castration alone or in combination with daily injections of estradiol-17β on tissue levels of prostaglandins (PGs) was evaluated in the Dunning R3327 rat prostatic adenocarcinoma model. Within 3 days, castration alone induced significant (p 0.05). The decreased PG levels remained low after the 6-wk period of study. Combined castration and estrogen treatment caused a further suppressive effect on tissue content of PGE2 compared to castration alone (-46%, p<0.01, n=5) but not in other PGs measured. Since estrogen treatment caused an almost complete inhibition of tumor growth, this effect may, at least in part, be due to decreased local production of PGE2.
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