Abstract
To better understand the complex protein interactions involved in cardiac muscle contractile activation we have developed a series of troponin C (cTnC) variants with increased or decreased Ca2+ binding affinity (in solution) that alter Ca2+ regulation of force development. We have previously reported that increasing or decreasing Ca2+ binding affinity by substitution of glutamine for leucine at residue 48 (L48Q cTnC) or isoleucine at residue 61 (I61Q) increased or decreased (respectively) Ca2+ sensitivity of steady state force in rat skinned trabeculae.
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