Abstract
AbstractThe influences of various carbon sources on fungal morphological changes and lovastatin production were investigated in submerged cultivation of a mutant of Aspergillus terreus. Lactose produced the least biomass (2.3 ± 0.15 gDCW l−1); however, the highest maximal specific lovastatin productivity (ρmax) was obtained. Glycerol achieved the highest lovastatin titer (937.5 ± 12.5 mg l−1), while soluble starch resulted in the highest biomass (12.05 ± 0.05 gDCW l−1) and the second highest lovastatin titer (501.3 ± 23.4 mg l−1). With the carbon source turning to be more easily metabolized, the values of ρmax dropped gradually while the corresponding Dp and mean filament ratio rose tardily. The value of ρmax (19.8 mg gDCW−1 d−1) was obtained in the presence of lactose while glucose resulted in the least ρmax (3.0 mg gDCW−1 d−1). This led to a 6.6‐fold decrease. The corresponding Dp and mean filament ratios appeared to reverse the effects, thus producing 1.9 and 3.3‐fold increases, respectively. The slowly utilizable carbon sources regulated the lovastatin production through both the inducement of fungal morphology differentiation and the control of metabolic regulation. Copyright © 2009 Curtin University of Technology and John Wiley & Sons, Ltd.
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