Abstract
Although several pharmaceutical investigations have been attemped to eradicate middle ear effusion (MEE), there has been no conservative therapy fully effective, convenient, and safe. Disturbance of the mucociliary transport system and release of proteolytic enzymes in the tympanic cavity and eustachian tube are probably the major pathogenesis of OME. This study was designed to investigate the therapeutic efficacy of S-carboxymethylcysteine (S-CMC), which restores the mucociliary clearance in experimental OME.Existance of MEE was diagnosed by observation of tympanic membrane using a fiberscope and by tympanogram.Oral administration of S-CMC in dose of 200mg/kg was more effective than that of dose 100 mg/kg. It was found that S-CMC is an effective drug for the early cure of experimental OME.Results of this study showed the efficacy of S-CMC to protect and restore the mucociliary transport system in the middle ear against experimental OME.
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