Abstract
The coronary vasodilator drugs carbochromen and dipyridamole were capable of increasing local myocardial blood flow and decreasing myocardial metabolic heat production both in the normal canine myocardium and in the myocardium rendered ischaemic by acute ligation of a coronary artery. This is taken as further evidence for the existence of an active myocardial vasoconstrictor reflex, triggered off by coronary ligation.
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