Abstract
BackgroundThe thermogenic and metabolic properties of capsinoids appear to mimic those of the more pungent sister compound capsaicin. However, few data exist on how capsinoid ingestion affects energy expenditure in humans and no data exist on its interaction with exercise. We aimed to determine how ingestion of capsinoids affected energy expenditure, lipid oxidation and blood metabolites at rest and during moderate intensity exercise.MethodsTwelve healthy young men (age = 24.3 ± 3 yr, BMI = 25.5 ± 1.7 kg·m-2) were studied on two occasions in a double-blind design following ingestion of either placebo or 10 mg of purified capsinoids at rest, after 90 min of cycling at 55% VO2 peak, and for 30 min into recovery. Subjects ingested the capsules 30 min prior to exercise.ResultsAt rest, following ingestion of capsinoids, we observed increases in VO2 and plasma norepinephrine levels, and decreases in concentrations of serum free fatty acids, plasma glycerol and the respiratory exchange ratio (all P < 0.05). At exercise onset, we observed a blunted accumulation of blood lactate with capsinoid ingestion vs. placebo (P < 0.05). There were no other significant differences between the conditions during or post-exercise.ConclusionThe ingestion of 10 mg of capsinoids increased adrenergic activity, energy expenditure, and resulted in a shift in substrate utilization toward lipid at rest but had little effect during exercise or recovery. The changes we observed confirm previous data on the thermogenic and metabolic effects of capsinoids at rest and further promote its potential role as an adjunct weight loss aid, in addition to diet and exercise.
Highlights
Capsinoids are non-pungent analogues of capsaicin derived from the CH-19 sweet pepper [1]
Ingestion of capsinoids have been shown in most studies [2,3,4,5] but not all [6] to increase resting oxygen consumption, body temperature, and lipid oxidation in humans
We proposed that capsinoid ingestion 30 min prior to exercise would generally induce metabolic changes consistent with increased metabolic rate and lipid oxidation, namely: elevate resting oxygen consumption; a shift in metabolism towards greater lipid oxidation; and increase catecholamine release consistent with a stimulation of the adrenergic system
Summary
Capsinoids are non-pungent analogues of capsaicin derived from the CH-19 sweet pepper [1]. Ingestion of capsinoids have been shown in most studies [2,3,4,5] but not all [6] to increase resting oxygen consumption, body temperature, and lipid oxidation in humans. A major difference, is that capsinoids are broken down in the intestinal tract to yield vanillyl alcohol and a fatty acid [7,8,9]. Capsinoids and capsaicin affect metabolism and thermogenesis in similar ways, but there are relevant differences. Few data exist on how capsinoid ingestion affects energy expenditure in humans and no data exist on its interaction with exercise. We aimed to determine how ingestion of capsinoids affected energy expenditure, lipid oxidation and blood metabolites at rest and during moderate intensity exercise.
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