Effects of capsicoside G on lipolysis and fatty acid oxidation in 3T3‐L1 adipocytes

Abstract

We have previously demonstrated that capsicoside G, a furostanol saponin, isolated from pepper seeds, inhibited adipogenesis in 3T3‐L1 adipocytes. However, the effects of capsicoside G on lipolysis and fatty acid oxidation remain unclear. The aim of this study was to extend the anti‐obesity investigation of capsicoside G by examining its effect on lipolysis and fatty acid oxidation in mature 3T3‐L1 adipocytes. Capsicoside G promoted lipolysis of adipocytes, which effectively decreased the intracellular triglyceride concentration of adipocytes and increased glycerol released into the medium. The increased lipolysis was accompanied by an augmentation in the expression of adipose triglyceride lipase and hormone‐sensitive lipase. Furthermore, capsicoside G also induced the expression of fatty acid oxidative genes such as peroxisome proliferator activated receptor α and carnitine palmitoyltransferase‐1 in mature 3T3‐L1 adipocytes. These results suggest that capsicoside G exerts anti‐obesity property by stimulating lipolysis and fatty acid oxidation in adipocytes.This abstract is from the Experimental Biology 2018 Meeting. There is no full text article associated with this abstract published in The FASEB Journal.