Abstract
This study aimed to determine the effects of alcoholic and aqueous extracts of caper (Capparis Spinosa) and acetic acid on serum lipid profile and proteins levels in mice. Sixty adult mice with an average weight of 24±4 g grams were divided into four groups (15 mice for each). The first group (G1) was administrated daily with an oral dose of caper alcoholic extract (200 mg/kg) for 28 days. The second group (G2) was administrated daily with an oral dose of caper aqueous extract (200 mg/kg) for 28 days. The third group (G3) was administrated with a daily dose of 10 % acetic acid (2 ml/kg) for 28 days. The fourth Group (G4) was administrated daily with distilled water for 28 days, as a control group. The levels of lipid profile parameters, blood urea, total protein, albumin, and globulin were determined. The results showed a significant reduction (P≤0.05) in cholesterol and triglyceride levels in mice that were treated with alcohol or aqueous extracts of caper compared with acetic acid-treated and control groups. On the other hands, the results showed a significant reduction (P≤0.05) of blood urea levels in mice that were treated with alcohol or aqueous extracts of caper compared with acetic acid-treated and control groups. While the results recorded non-significant differences in the levels of total protein, albumin, and globulin in the serum of mice of different treatment groups. From the results, it can be concluded that caper has protective effects via acting to improve the lipid profile and urea level in the blood of mice.
Highlights
Obesity is a major endemic problem in the world, while coronary artery disease is still the leading cause of global death rates [1]
Lipids are transformed to triacylglycerol degraded to free fatty acid, while free cholesterol is transformed into very low-density lipoproteins with a variety of apoproteins [4]
The results revealed a significant reduction (P ≤0.05) in the levels of cholesterol and triglyceride of mice treated with alcohol or aqueous extracts of caper compared with acetic acid-treated group and the control
Summary
Obesity is a major endemic problem in the world, while coronary artery disease is still the leading cause of global death rates [1]. ) في اليهريا في الجم في الفئ اخن التي تم معاملتيا بالمدتخلصP≤0.05( أظيخت النتائج انخفا ًضا معنهًيا، بينما سجلت.الكحهلي أو المائي للكبار مقارنة مع المجمهعة المعاملة بحامض الخليك والمجمهعة الديطخة الألبهمين والكلهبيهلين في مصل الفئ اخن بين المجمهعات، النتائج فخوق غيخ معنهية في البخوتين الكلي من النتائج يمكن أن ندتنتج أن نبات الكبار لو تأثيخ وقائي ويعمل على تحدين صهرة الجىهن.المختلفة Another study showed that mice treated with acetic acid had increased lipid oxidation and decreased hepatic triglyceride concentration [19].
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