Abstract
Abstract This study evaluated the antiarthritic and anti-inflammatory activities of calcium pentosan polysulfate (CaPPS), using a modified adjuvant-induced arthritis model in rats. A combined model of arthritis and air-pouch inflammation was developed in Wistar rats by subdermal injection of Mycobacterium tuberculosis (Mtb) into the tail base on day 0 followed by a second Mtb injection on day 10 into preformed, saline-filled, dorsal air pouches. Rats received either normal saline only (n=25) or CaPPS in saline administered subcutaneously at doses of 2.5 (n=5), 5 (n=5), 10 (n=5), or 20 mg/kg (n=10) 5 times per week over the study period. Animals were necropsied on day 17, and pouch fluid volume, total and differential white blood cell (WBC) counts, nitrite ion (the metabolite of the nitric oxide [NO] radical), prostaglandin E 2 (PGE 2 ), and interleukin-6 (IL-6) content were determined. In addition, IL-6 activity in serum samples collected at necropsy was evaluated. Results of this study showed that CaPPS at 10 and 20 mg/kg significantly reduced tail and paw swelling ( P 2 levels, it reduced total WBC counts ( P P 2.5 mg/kg ( P 2 levels in inflamed subcutaneous rat air-pouch fluids.
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