Abstract
AbstractThe effects of a calcium antagonist of the dihydropyridine type, feiodipine, on the cerebral circulation were studied in comparison with those of nicardipine in pancuronium-bromide immobilized unanesthetized dogs. Feiodipine (0.3–10 μg/kg, i.v.) and nicardipine (0.3-10 μg/kg, i.v.) produced a dose-related decrease in mean blood pressure with almost equal potencies. However, at a dose of 3 μg/kg, feiodipine produced a more prominent increase in cerebral blood flow (CBF) than nicardipine. Decreases in cerebral vascular resistance were significantly greater in the feiodipine group at doses of 0.3 and 3 μg/kg, when compared with the nicardipine group. Cerebral oxygen consumption calculated by multiplying the arte rio-venous difference of oxygen content by CBF was increased by these two drugs, but the changes were minimal. These data suggest that the increase in CBF produced by feiodipine and nicardipine was primarily due to the direct dilatation of the cerebral blood vessels.
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