Abstract

Hypertension and hyperlipidemia are major risk factors for coronary heart disease and atherosclerosis. Several studies have shown a decrease in cardiovascular disease by lowering blood pressure. However, there has been a failure to demonstrate a significant reduction in myocardial infarction, particularly in mildly hypertensive patients. Since many antihypertensive drugs alter plasma lipoprotein levels in an unfavourable way they may increase coronary risk and therefore offset the beneficial effects of lowering blood pressure. Other antihypertensive agents have few adverse or even beneficial effects on plasma lipoprotein levels (for review see 1). The mechanisms responsible for these drug effects have not been established. Furthermore it is not yet clear whether antihypertensive agents directly affect cellular lipid and cholesterol metabolism.

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