Abstract
ABSTRACTUsing an in vitro explant culture system of pig skin, the effects of calcium and calcium‐ionophore on the outgrowing epidermis were studied. The optimum concentration of calcium on the rates of epidermal outgrowth was 1.0 mM and that of mitosis was around 1.2 mM. Ionophore A23187 (Ionophore) significantly stimulated both the rates of epidermal outgrowth and the mitosis of the outgrowing epidermis. This stimulation was partially blocked by the addition of hydrocortisone.The cyclo‐oxygenation products, prostaglandins, failed to stimulate the rate of epidermal outgrowth. It appeared that the stimulatory effect of Ionophore on the outgrowing epidermis was due either to the activation of phospholipase A2 or to the activation of the lipoxygenase pathway.
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