Abstract
Both porcine calcitonin (CT) and bovine parathyroid hormone (PTH) increased the levels of cyclic adenosine 3',5'-monophosphate (cyclic AMP) in the whole kidney of rats in vivo andin the isolated renal cortical tubules of rats in vitro. Both hormones were without effect on cyclic AMP levels in the renal medullary tubules in vitro. Using doses that produce the maximal responses both in vivo and in vitro, the increments in cyclic AMP were greater with PTH than with CT, and additive effects were absent. Calcitonin and PTH producedan earlier peak in urinary excretion of cyclic AMP than in that of phosphate. These findings provide evidence that CT stimulates the production of cyclic AMP in the renal cortical tubules in vivo and in vitro, and suggest that there may exist a renal tubular cell population containing receptors for both hormones. The results are consistent with the contention that the phosphaturic effect of CT is mediated through the stimulation of adenyl cyclase-cyclic AMP system. (Endocrinology94:1...
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