Abstract
The regulatory effects of neuropeptides on skin immune cells in the neuroimmunomodulation process have gained more and more attention in chronic inflammatory skin diseases. Under psychentonia, stress and pressure, nerve fibers in local skin produce calcitonin gene-related peptide (CGRP)to regulate Langerhans cells, which are professional antigen-presenting cells in the epidermis. Recent studies have found that CGRP can affect not only the proliferation and differentiation of Langerhans cells, but also their antigen-presenting capacity. Moreover, CGRP can influence Langerhans cell-induced immune reactions by inhibiting the activation of nuclear factor kappa B (NF-κB)signaling pathway and expression of costimulatory molecules. Key words: Langerhans cells; Calcitonin gene-related peptide; Neuroimmunomodulation; Neuropeptides; NF-kappa B
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