Abstract
Cadmium and Selenium are ubiquitous metals in the environment I that induces a broad range of physiological dysfunctions. The purpose of this study was to investigate the chronic effect of Cadmium (Cd) and Selenium (Se) on rats blood parameters and histopathology of the liver in the male rats. Animals were divided at random into a control and treated groups (Cd and Se + Cd), both groups were fed with the same standard food, but Cadmium chloride, and mixture of Cadmium chloride +Selenium chloride were added to the drinking water of the experimental groups. At the end of the experiments periods ( 28 days ) the animals were sacrificed , blood samples were drawn via the dorsal vena cava , Hematocrit ( Hct % ) , hemoglobin ( Hb ) , number of erythrocytes count and of erythrocytes count were determined . Liver was dissected out for histological examination. There were different alteration in the blood parameters among different treated animals (Cd and Se + Cd) and controlgroups .They differences were statistically significant (P:S 0.05) with Cd treatment. Also results showed that the positive or negative alteration of blood parameters was not significant for Se + Cd mixture treated rats group.A number of morphological change were observed in the liver , including a nuclear damage , necrosis and cell death at cadmium treatment and pronounced recovery after co-selenium supplementation indicted a considerable antagonistic effects . It can be concluded that the Cd exposure impair certain hemorheological mechanism and increase tissue damage in liver, although Selenium showed beneficial effects to some extend. In summary, this study provides data on toxic effect in rats after dietary sub lethal supplementation to heavy metals.
Highlights
In recent years, increasing attention has been drawn to the effects of heavy metals present ubiquitously in the environment, on human and animal health .Heavy metals intoxication especially by lead, cadmium, arsenic and mercury constitutes treat to animal and human health [1]
A number of morphological change were observed in the liver, including a nuclear damage, necrosis and cell death at cadmium treatment and pronounced recovery after co-selenium supplementation indicted a considerable antagonistic effects
The major challenge in experimental ecotoxicological studies is to cope with the relative paucity of literature on toxicity induced by dietary exposure
Summary
In recent years, increasing attention has been drawn to the effects of heavy metals present ubiquitously in the environment, on human and animal health .Heavy metals intoxication especially by lead, cadmium, arsenic and mercury constitutes treat to animal and human health [1]. The most obvious .toxic effect of pollutants appears in the hematopoiesis process. It has been proposed that heavy metals acknowledge shortened life span of erythrocytes and inhibit of hemoglobin synthesis [2]. Cadmium is one of the most toxic substances in the environment with wide range of organ toxicity, along elimination half- life accumulates in blood and stored primarily in the kidney and liver and excreted through glomerular filtration in the kidney and may have toxic effect on several organs e.g hematopoietic system, the liver and kidney [3] , [4] and [5]. Xenobiotic is an influential factors, which may have direct or indirect effect by generation
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
