Abstract
1. 1. The roles of Ca 2+ and Mg 2+ in the transport of amino acids were examined in rat kidney cortex slices in vitro. The absence of either Ca 2+ or Mg 2+ from the incubation fluid was associated with increased inulin space and slightly decreased K + content of the slices although no significant alterations of total tissue water nor Na + content were noted. Decreased net accumulation of glycine, cycloleucine and α-aminoisobutyric acid were found upon removal of either divalent cation from the incubation fluid with no corresponding effects upon efflux from prelabeled tissues. No effects of divalent cations were noted upon lysine transport. 2. 2. It is concluded that Ca 2+ and Mg 2+ have critical roles in the transport of amino acids in rat cortical slices which are related to an active pump mechanism.
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