Abstract
SummaryA method is described for detecting precursors of urinary 17-KS in normal female rats. Using it, 2 pairs of compounds which differed in hydroxylation at C-17 were tested and those 2 possessing this grouping were found to be eliminated in part as urinary 17-KS. One 17-hydroxylated steroid, pregnenetriolone did not act as a 17-KS precursor. These observations bring into question the assumed secretion of adrenal androgens, since they are consistent with the view that such might arise from the degradation of non-an-drogenic hormones.
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