Abstract
The aim of the present study was to investigate the effects of an antisense ologodeoxynucleotide (AS-ODN), complementary to the initiation codon of rat c-fos mRNA, on Fos protein expression in the medial vestibular nuclei (MVN) and behavioural recovery ('vestibular compensation') following unilateral labyrinthectomy (UL) in guinea pig. The AS-ODN (1 mM), which was infused into the IVth ventricle close the the MVN beginning at 1 h pre-UL and continuing to 5 h post-UL, inhibited expression of the Fos protein in the MVN; however, a mis-sense ODN (MS-ODN) had a similar effect, suggesting a non-sequence-specific mechanism of action. Neither the AS-ODN nor the MS-ODN had any significant effect on vestibular compensation relative to vehicle controls.
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