Abstract
Cytochrome P-450 content and NADPH-cytochrome P-450 reductase activity were measured in liver microsomes prepared from male weanling rats fed low-fat, high-saturated fat or high-polyunsaturated fat diets with or without butylated hydroxytoluene (BHT) and 2-acetylaminofluorene (AAF). The inclusion of BHT and/or AAF in the diets consistently produced marked decreases in cytochrome P-450 reductase activity, regardless of the amount and type of dietary fat. In contrast, there was no inhibition of reductase activity when the compounds were added in vitro to liver microsomes.
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