Effects of brief mindfulness on anxiety-provoked adverse events during ultrasound-guided fine-needle aspiration biopsy of thyroid nodules

Abstract

PurposeThis study aims to test the effectiveness of brief mindfulness for anxiety-provoked adverse events during ultrasound-guided fine needle aspiration biopsy (FNAB). ResultsA total of 439 patients were randomized to two groups. The ratio of anxiety in all patients with TN before FNAB was 25.3%, which was correlated with the intraoperative stress index. The FNAB-related adverse events in the control group were significantly higher than in the intervention group (65.0% vs. 17.3%; odds ratio [OR], 0.11 [95%CI, 0.56–0.74]; P < 0.001), especially for emotional stress (61.5% vs. 15.5%, odds ratio [OR], 0.12 [95%CI, 0.53–0.70]; P < 0.001) and patient's noncooperation (12.0% vs. 1.8%, odds ratio [OR], 0.14 [95%CI, 0.06–0.18]; P = 0.002). The stress index in control group were significantly higher than in the intervention group (87.82 [range, 27–99] vs 83.48 [range, 31–95]; P < 0.001). ConclusionsBrief mindfulness decreased anxiety-provoked adverse events and stress index in patients with thyroid nodules during FNAB.