Abstract
Type 1 diabetes (T1D) is an autoimmune disease characterized by the selective destruction of pancreatic beta cells. In addition to genetic factors, enteroviruses have been considered the main environmental factor involved in this pathology. Therefore, the objective of this study was to evaluate the effects of streptozotocin-induced diabetes and bovine enterovirus (BEV) on liver and kidney pyruvate kinase activity in rats. Fourteen male Wistar rats were divided in three groups: control, diabetes and a third group, which was fed with water experimentally contaminated by BEV. Increased blood glucose levels were found in both diabetes and enterovirus groups, whereas there were no alterations in the lipid profile. A reduced pyruvate kinase activity was observed in the liver and kidney of animals from diabetes and enterovirus groups. Under our experimental conditions, the ingestion of water experimentally contaminated by BEV induced alterations in glycaemia, and also interfered in the pyruvate kinase activity in liver and kidney of the rats, which might be one of the possible mechanisms involved in the T1D development.
Highlights
Type 1 diabetes (T1D) is a chronic disease which results from the impaired metabolism of glucose, leading to a high concentration of glucose in the circulation (Antonelli, Ferrari, Di Domenicantonio, Ferrannini, & Fallahi, 2015)
An increase in blood glucose levels was observed in diabetes and enterovirus groups when compared to the control group: F (2, 10) = 690.04; p< 0.001 and p< 0.05; respectively, indicating the success of the STZ application and a potential role for enterovirus in increasing glycaemia (Figure 1)
When analyzing the pyruvate kinase activity in the liver, a statistically significant reduction was observed in diabetes and enterovirus groups when compared to the control: F(2, 11) = 5.24, p < 0.05 for both groups (Figure 3)
Summary
Type 1 diabetes (T1D) is a chronic disease which results from the impaired metabolism of glucose, leading to a high concentration of glucose in the circulation (Antonelli, Ferrari, Di Domenicantonio, Ferrannini, & Fallahi, 2015). It is characterized by the progressive and selective destruction of pancreatic beta cells in genetically predisposed individuals during childhood and adolescence (Richardson, Willcox, Bone, Morgan, & Foulis, 2011), some epidemiological studies have indicated that its incidence may be comparable to adults in some countries (Molbak, Christau, Marner, Borch-Johnsen, & Nerup, 1994). These viruses are tolerant to residual chlorine from sewage treatment and to a wide range of temperatures and salinities, which facilitates their survival in water resources (Gregory, Litaker, & Noble, 2006)
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
