Effects of BMP 2 and 7, as a protein or a transfected gene, on oral squamous carcinoma cells

Abstract

Statement of the Problem: Exogenous bone morphogenic protein (BMP) has been approved for use as an adjunct in orthopedic repair of critical defects of the long bones and in spinal fusion. It is not, however, recommended in the reconstruction of cranio and maxillofacial skeletal defects. The use of exogenous bone morphogenic protein (BMP) and/or transfected BMP genes in the replacement of bone lost during the surgical ablation of oral squamous carcinoma is a promising application. The effect of these modalities on residual carcinoma cells is unknown. The objective of this study is to evaluate the effect of, and relationship between, bone morphogenic proteins on oral squamous carcinoma cells. Specifically, effects of BMP as both a protein and a transfected gene, on proliferation, angiogenic potential, and osteogenic potential of oral squamous carcinoma cells were examined. Also investigated was the qualitative expression of BMP and BMP receptor expression by squamous carcinoma cells.