Abstract
16 patients who had severe dysplasia of the uterine cervix were given Bleomycin suppository to the uterine cervix, and the effect of Bleomycin against severe dysplasia. was cytologically studied.We examined the cytologic specimens at 1 day, 7 days and 1 month of the Bleomycin application. Bleomycin was. administered in a dose from 30-150mg, to a total dose from 90-300mg.The cytological effects of Bleomycin were enlargement of cytoplasm and nucleus, appearance of multinucleated cells, vacuolization of cytoplasm and appearance of reparative cells. These effects were a marked in the specimens at 7 days of the Bleomycin treatment. Duration of regression of severe dysplasia was about 7.1 months and there was no recurrent dysplasia during a 3.5-year follow-up.
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