Abstract
All bisphosphonates are similar in terms of their inhibitory effects on bone resorption, but seems to have different effects on inflammatory processes. For example, clodronate and tiludronate have anti-inflammatory and antiarthritic activity in animals, while aminobisphosphonates exacerbate experimental arthritis in mice. Further, aminobisphosphonate induce acute phase response in patients, while non-aminobisphosphonates do not. During the last few years, we have explored the effects of various bisphosphonates on the inflammatory processes in activated macrophages in vitro.
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