Abstract
Bisphenol-A (BPA) is one of the highest volume chemicals produced world-wide and used in the manufacture of plastics and epoxy resins that are pervasive in our environment and daily lives. The present research was carried out to investigate the effects of two different doses of Bisphenol-A (BPA) on the body weight, hematological parameters and patho-physiological changes of kidney in mice. For this study, fifteen mice, 6 to 8 weeks of age with an average bwt 27.10±0.5 gm, were randomly divided into three groups (n= 5). Group A (control) received only normal mouse pellet while group B and group C received pellet mixed with BPA @ 50 mg and 100 mg / kg bwt daily for 12 weeks, respectively. At the end of the experiment, blood and tissues were collected and processed for hematological and histopathological examination. Results showed that BPA- treated mice caused significant elevation (p<0.01) in weight gain even treated with low dose (50mg) of BPA. The mice exposed to high dose of BPA (100 mg) showed marked reduction (p<0.05) in total erythrocyte count (TEC), significant decreased (p<0.01) in hemoglobin concentration (Hb) and packed cell volume (PCV). Histopathological alterations were detected in the kidneys of BPA-treated mice. In conclusion, this study suggested that BPA exerts deleterious impacts on hematological parameters including association with renal injuries.
 Asian J. Med. Biol. Res. December 2020, 6(4): 635-640
Highlights
Bisphenol-A (BPA) is a high molecular polymer compound that generally used in the manufacture of polycarbonate plastic, water and baby bottles, epoxy resins, inside coating of food cans and dental sealants (Hernandez- Rodriguez et al, 2007)
Mice treated with both BPA 50 mg and BPA 100 mg showed that there was significant (p
The present findings are closely related with the findings of Miyawaki et al (2007); Newbold et al (2008) and Rubin and Suto, 2009 and they reported that BPA has a great influenced on body weight gain by fat accumulation, facilitates gluconeogenesis, adiponectin secretion and adipocyte differentiation
Summary
Bisphenol-A (BPA) is a high molecular polymer compound that generally used in the manufacture of polycarbonate plastic, water and baby bottles, epoxy resins, inside coating of food cans and dental sealants (Hernandez- Rodriguez et al, 2007). BPA is one of the highest volume industrial chemicals produced and global consumption of BPA in 2011 was predicted to exceed 5.5 million metric tons (Greiner et al, 2007). It is a pseudo-persistent chemical, which despite its short half-life is ubiquitous in the environment because of continuous release (Oehlmann et al, 2009). BPA has been detected in drinking water and food of humans and animals due to ubiquity use of plastic products (Michalowicz, 2014). BPA is released by food and beverage containers (El-Missiry et al, 2014) and route of exposure is ingestion, inhalation and skin penetration (Rubin, 2011). To our knowledge there is few researches have done about BPA in Bangladesh
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