Abstract
The interrelationship between insulin deficiency and biotin deficiency and its relation to carbohydrate metabolism has been studied. Severe biotin-deficient animals show no change in blood sugar levels. Administration of equal amount of anti-insulin serum increased the blood sugar levels to the same extent in normal and biotin-deficient animals, indicating insulin levels were unaltered in biotin deficiency. Oxidation of C 14-glucose to CO 2 is also unaltered. C 14O 2 incorporation into glucose is slightly decreased in biotin-deficient animals. Anti-insulin serum treated biotin-deficient animals show three- to fourfold increase in C 14O 2 incorporation into glucose. Incorporation of 2-C 14-acetate and 2-C 14-propionate into glucose, glycogen, and CO 2, and C 14O 2 into glucose and glycogen is unaltered in biotin-deficient animals. However, there is a significant decrease in the incorporation of these substrates into long-chain fatty acids.
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