Abstract
Objective: biological age has been given a large role in determining the significance and contribution to the general concept of risk factors in recent years. The relevance of determining the rate of aging is also due to the fact that the rate of aging may have a real prognostic value for assessing the health of both an individual and groups exposed to one or another risk factor. The aim of the present paper was to study the biological age, to assess the rate of aging in persons with high cardiovascular risk (CVR), as well as to carry out search for possible correlations of age-related indices of aging and some risk factors. Methods: During 2016-2018, 96 patients (42 men and 54 women), whose mean age was 62.66 ± 4.21 years, with AH stage II (disease duration of 10.2 ± 3.7 years) and DM2T, disease duration of 4.1 ± 2.4 years) were included in the study. The biological age and rate of aging was investigated by the method of V.P. Voitenko et al. Results: Physiological aging was observed in 9.38% (9/96) patients, in 31.25% (30/96) there was a delayed rate of aging, in 59.38% (57/96) - an accelerated rate of aging (ARA). ARA was characterized by a more pronounced body mass index, fasting blood glucose level, insulin resistance degree. In men, ARA was observed 2 times more frequently than in women. The most significant correlations between the indices characterizing the biological age and the rate of aging were recorded with systolic, diastolic and pulse arterial pressure. Conclusion: Thus, the complex of anthropometric and metabolic disorders can act as an initiating syndrome of accelerated aging, thereby aggravating the existing cardiovascular risk.
Highlights
Введення: біологічному віку в останні роки відводиться велика роль у визначенні значущості та внеску в загальну концепцію факторів ризику
Objective: biological age has been given a large role in determining the significance and contribution to the general concept of risk factors in recent years
The long-term study of various risk factors of cardiovascular diseases has led to the emergence of a concept, which is a scientific evidence base for preventive cardiology and has been reflected in the development of various scales used to calculate the total risk and prognosis (SCORE, Framingham scale, etc.) [7,14,15]
Summary
Введення: біологічному віку в останні роки відводиться велика роль у визначенні значущості та внеску в загальну концепцію факторів ризику. Матеріали та методи: Фізіологічне старіння спостерігалося у 9,38% (9/96) пацієнтів, у 31,25% (30/96) мав місце уповільнений темп старіння, у 59,38% (57/96) - прискорений темп старіння (ПТС ). Найбільш значущі кореляційні зв'язки між показниками, що характеризують біологічний вік і темпи старіння, були з систолічним, діастолічним і пульсовим артеріальним тиском. Arterial hypertension (AH) and coronary heart disease (CHD) continue to be a relevant issue within the structure of cardiovascular diseases (CVD) and determine the structure of cardiovascular morbidity and mortality The reasons for their onset and progressing are not completely understood yet, but due to scientific studies, the risk factors have been identified as contributing to their development and progression. Biological (functional) age is a fundamental characteristic of the development rate (aging), it permits to assess the degree of true aging, the level of vitality and general health of the body. If it is impossible to influence the calendar age, biological age is a variable value and depends on many factors
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