Abstract
Cataracts are one of the most causes of blindness in the world. Oxidative stress can form pathological conditions such as cataracts. This oxidative stress ability can be measured by the malondialdehyde (MDA) biomarker. Binahong leaves (Anredera cordifolia (Tenore) Steenis) are native plants from Indonesia that are used to treat various diseases including cataract treatment. Binahong leaf (Anredera cordifolia (Tenore) Steenis) has a high amount of flavonoids and is rich in antioxidants that can be used to treat cataracts. Objective. The purpose of this study was to assess the effect of binahong leaf extract on the levels of MDA in a goat lens with cataract-induced material. Method. As many as possible, 40 goat eye lenses were divided into several groups, namely, group I normal lenses as controls (glucose 5.5 mM), group II lenses were cataract induced with glucose concentration of 55 mM, group III lenses with glucose 55 mM + binahong leaf extract (100 μg/ml), group IV lens with glucose 55 mM + binahong leaf extract (200 μg/ml), and group V lens with glucose 55 mM + quercetin (positive control). Biochemical parameters measured in the lens homogenate are malondialdehyde lens morphology in all groups' observations and comparisons made. Results. The results of the study found that the lens group with the addition of binahong extract showed more results transparency compared to lens groups induced by glucose concentrations of 55 mM). This shows that the diabetic cataract group experienced high oxidative stress due to the accumulation of sorbitol compounds derived from glucose which caused turbidity in the goat eye lens and increased levels of lens MDA. Binahong levels at concentrations of 100 or 200 can inhibit MDA production. Conclusion. Binahong (Anredera cordifolia (Tenore) Steenis) extract has the ability to inhibit the production of MDA levels. In glucose-induced goat lenses, binahong extract and quercetin show antioxidant and anticataract properties.
Highlights
A cataract is a condition of pacification of the eye lens that reduces the amount of light entering the eye, so that it can cause blindness [1]. e World Health Organization (WHO) suggests that by 2020, the number of blind people will reach 90 million globally [2, 3]. e prevalence of cataract increases with age, from 5% for patients aged 52–62 to 64% for patients over 70 years, in Europe [4]. e most common symptoms of cataract are impaired vision, decreased contrast sensitivity, color disturbance, and glare [5]
Oxidative stress is a condition where the amount of free radicals exceeds the amount of antioxidants found in the body. is condition can cause pathological conditions, one of which is cataract. is oxidative stress can be defined as an increase in reactive oxygen species (ROS) and a physiological decrease in endogenous antioxidants
On exposure to high concentrations of glucose, the use of glucose in the lens begins through the sorbitol pathway. e accumulation of polyols causes overhydration and oxidative stress resulting in the emergence of cataract generation [24]
Summary
A cataract is a condition of pacification of the eye lens that reduces the amount of light entering the eye, so that it can cause blindness [1]. e World Health Organization (WHO) suggests that by 2020, the number of blind people will reach 90 million globally [2, 3]. e prevalence of cataract increases with age, from 5% for patients aged 52–62 to 64% for patients over 70 years, in Europe [4]. e most common symptoms of cataract are impaired vision, decreased contrast sensitivity, color disturbance, and glare [5]. A cataract is a condition of pacification of the eye lens that reduces the amount of light entering the eye, so that it can cause blindness [1]. Cataracts can be caused by many factors such as oxidative stress, UV radiation, calcium levels in the lens, and complications of diabetes mellitus (diabetic cataracts) [6, 7]. Cataractogenesis e Scientific World Journal in diabetes mellitus is mainly due to generation of free radicals causing oxidative stress. Oxidative stress is a condition where the amount of free radicals exceeds the amount of antioxidants found in the body. Is oxidative stress can be defined as an increase in reactive oxygen species (ROS) and a physiological decrease in endogenous antioxidants [8] Oxidative stress is closely related to cataracts. Malondialdehyde is a by-product of mutagenic lipid peroxidase [9]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
