Abstract
The high frequency of ST-segment abnormalities in response to exercise in premenopausal women is widely recognized. 1 An incidence of 14 to 67% of false-positive exercise responses has been reported. 2 It has been suggested that ST-segment shifts among women, in the absence of coronary artery disease, may be related to relatively high estrogen levels. 3,4 Although this hypothesis was not thoroughly investigated, several reports suggested that there is a relationship between high estrogen level and ST-segment response during exercise. 4,5 To clarify the role of sex hormones, estrogen and progesterone in evoking abnormal electrocardiographic responses during exercise, the present study was designed. In this study ST-segment response at peak exercise was assessed before and after unilateral versus bilateral salpingo-oophorectomy operation. This can serve as a model for drastic changes in hormonal levels, and it may clarify the issue of the effect of sex hormones on ST changes.
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