Abstract
Esophageal cancer has one of the highest mortality rates compared to other types of cancer. Tissue engineering promises a bio-artificial prosthesis for enhanced surgical treatment. To facilitate the tissue engineering of the esophagus, a bioreactor capable of two-dimensional mechanical strain was designed and fabricated. Esophageal smooth muscle cells are seeded onto oxygen plasma treated polyurethane sheets and mechanically stimulated for 3 days at 420 cycles/day. The cells are then assessed for cell alignment by phase contrast microscopy and cell proliferation by MTS assay. After mechanical stimulation, the smooth muscle cells showed alignment under varying biaxial strain conditions in different regions of the bioreactor while the cell proliferation assay suggests the possibility of the change in the metabolic and phenotypic state of the cells over the 3 days of mechanical stimulation.
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