Abstract
1821 The purpose of this investigation was to compare exercise treadmill test results of children with Long QT Syndrome (LQTS) on beta-adrenergic blockade medications with those of children on beta-blockers without LQTS (BB) and controls (C). The LQTS group consisted of 14 patients (Propranolol=7, Atenolol=4, Nadolol=3) with both familial and idiopathic LQTS. The BB group included 5 patients with hypertrophic cardiomyopathy, syncope, or ventricular tachycardia who were on beta-blockade medications (Propranolol=3, Atenolol=2). Group C consisted of 42 children with innocent murmurs, mitral valve prolapse, or musculoskeletal chest pain. All subjects underwent a modified Bruce protocol treadmill stress test. (Table)TablePatients in groups LQTS and BB achieved 70% of peak heart rate and 82% of endurance time compared to group C. In conclusion, appropriate doses of beta-adrenergic blockade medications blunt exercise tolerance, in addition to resting and exercise peak heart rates, in children with Long QT Syndrome commensurate with other children on beta-blocker therapy.
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