Abstract
Cryogenine and a series of ataractic agents inhibit both cotton pellet-induced granuloma formation and carrageenin-induced pedal edema in the rat. Chlorpromazine, reserpine, and one group of benzoquinolizine derivatives (tetrabenazine, benzquinamide, and 2-ethyl-2,3,4,6,7,11b-hexahydro-2-hydroxy-3-isobutyl-9,10-dimethoxy-1H-benzo[h]quinolizine) inhibited inflammation concomitant with but not dependent upon apparent endogenous steroid release. A second type of benzoquinolizine (3-ethyl-2,3,4,6,7,11b-hexahydro-2-hydroxy-2-isobutyl-9,10-dimethoxy-1H-benzo [h]quinolizine) decreased the inflammatory response without apparent adrenal stimulation. Cryogenine was qualitatively different from the other compounds as it appeared dependent upon an intact pituitary-adrenal axis for anti-inflammatory effectiveness.
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