Abstract
Effects of Benzo(e)Pyrene, a toxic component of cigarette smoke, on Müller Cells (MIO-M1) in vitro
Highlights
Age-related macular degeneration (AMD) is a very common cause of blindness in the aged population of the Western world [1]
In the present study we evaluated the effects of B(e)P on the human MIO-M1 cell line, which is representative of Müller glial cells of the human retina
We found that MIO-M1 cells treated with different concentrations of B(e)P showed decreased cell viability, increase in caspase 3/7 activity, increase in reactive oxygen species (ROS)/RNS production and a decrease in mitochondrial membrane potential
Summary
Age-related macular degeneration (AMD) is a very common cause of blindness in the aged population of the Western world [1]. One of the risk factors which is statistically associated with both the dry and the wet forms of macular degeneration is smoking [2]. The dry form can have extensive retinal pigment epithelial (RPE) cell damage which can lead to geographic atrophy. Both forms of AMD have devastating effects on central vision [3]. AMD is a major cause of vision loss in the elderly American population and the prevalence of AMD is currently estimated to be 1.75 million in United States [4]
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