Effects of benzlkonium chloride on the properties of artificial tears based on carboxymethylcellulose polymer for cured of animal eye

Abstract

This work aims to mointer the effects of benzalkonium chloride preservative material on properties and performance of artificial tear based on carboxymethyl cellulose, which used to overcome some of symptoms of eyes diseases, like dehydration and irritation. Therefore two formulation prepared, one of them contains surfactant by 0.1 wt%, while the other not. Different tests were carried out, such as osmosmality, animal, rheology, zeta potential, mobility, density, PH and FTIR. Results showed that the preservative material acts as cationic surfactant and as biocide agent and causes effects, such as decreasing the osmilatory from 287 to 283 Osm/L, from 6.6 to 6.44, increasing the zeta potentioal from -20 to -31 mV and mobility from -1.8 to -2.1 (m/s)/(V/cm). From the view point of rheology properties, benzalkonium chloride addition make the viscosity –shear rate relation more closer to the standard tear behavior with shear thinning behavior.