Abstract
We describe the effects of Bay K 8644, a dihydropyridine-sensitive Ca 2+ channel agonist, on [ 3H]norepinephrine (NE) release from the hypothalamus of spontaneously hypertensive rats (SHR). The electrical stimulation-evoked [ 3H]NE release was greater in hypothalamic slices of SHR than in those of Wistar Kyoto (WKY) rats. Bay K 8644 (10 −6 M) significantly increased the stimulation-evoked [ 3H]NE release in SHR. However, the agonist showed no significant effects in normotensive WKY rats. The results suggest that the dihydropyridine-sensitive Ca 2+ channels might participate actively in the regulation of the central sympathetic tone of hypertension.
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