Abstract
Effects of Baicalin on ATP Levels in the Prefrontal Cortex of Mice Exposed to Chronic Unpredictable Mild Stress
Highlights
Depression is mainly manifested as persistent low mood, anhedonia, energy loss, and sleep disturbance (Belmaker and Agam 2008; Willner, Scheel-Kruger, and Belzung 2013)
This study aimed to investigate the antidepressant effects of baicalin and explore its potential mechanism in a mice model of depression induced by chronic unpredictable mild stress (CUMS)
In the sucrose preference test (SPT) (Fig. 1a), the sucrose preference was significantly reduced in CUMS group compared with the control group [t (16) = 9.025, p < 0.001], which was reversed by baicalin [F (2, 24) = 12.818, p < 0.001] and fluoxetine treatment [F (2, 24) = 12.818, p = 0.023]
Summary
Depression is mainly manifested as persistent low mood, anhedonia, energy loss, and sleep disturbance (Belmaker and Agam 2008; Willner, Scheel-Kruger, and Belzung 2013). The lower energy levels in the brain of depression patients and animal models could be significantly reversed by antidepressants (Glombik et al 2020; Park et al 2020; Weckmann et al 2017; Lam et al 2017). Direct intracerebroventricular injection of ATP into the brain could significantly improve the depression-like behavior of chronic unpredictable mild stress (CUMS)-exposed mice (Cao et al 2013). These findings suggested that improving the energy level in the brain may be one of the new strategies to treat depression
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
