Abstract
We have studied the effects of baicalein on leukotriene C4 biosynthesis induced by calcium ilonophore A 23187 in human peripheral polymorphonuclear leukocytes. Baicalein inhibited calcium ionophore-induced leukotriene C4 biosynthesis in human polymorphonuclear leukocytes. The concentration of baicalein required for 50% inhibition(IC50) of leukotriene C4 formation was 6.00×10-7 M at a calcium ionophore concentration of 1 μg/ml; at 0.1 μg/ml it was 2.05×10-7 M.
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