Abstract
Aim To reveal the role of bacterial translocation (BT) and autophagy in severe acute pancreatitis-induced acute lung injury (SAP-ALI). Methods Rats were separated into a control (sham-operation) group (n = 10) and a SAP group (n = 10) and a SAP group (Results Levels of TNF-α, IL-6, lipase, and amylase in the SAP group were significantly higher than those in the control group (P < 0.01). Histopathological score and W/D ratio of the lung in the SAP-BT(+) group were significantly higher than that in the SAP-BT(-) group (P < 0.01). Histopathological score and W/D ratio of the lung in the SAP-BT(+) group were significantly higher than that in the SAP-BT(-) group (P < 0.01). Histopathological score and W/D ratio of the lung in the SAP-BT(+) group were significantly higher than that in the SAP-BT(-) group (P < 0.01). Histopathological score and W/D ratio of the lung in the SAP-BT(+) group were significantly higher than that in the SAP-BT(-) group (P < 0.01). Histopathological score and W/D ratio of the lung in the SAP-BT(+) group were significantly higher than that in the SAP-BT(-) group (P < 0.01). Histopathological score and W/D ratio of the lung in the SAP-BT(+) group were significantly higher than that in the SAP-BT(-) group (Conclusions BT can aggravate SAP-ALI with the increasing oxidative stress level, which may be related to the decrease of autophagy level.
Highlights
Severe acute pancreatitis (SAP) is a dangerous acute abdominal disease, which can cause systemic inflammatory response and rapidly accumulate multiple organs
The score of lung injury and result of lung W/D ratio were contrary to the expression of autophagy proteins. These results suggest that bacterial translocation (BT) can aggravate SAP-Acute lung injury (ALI), which may be related to the decrease of autophagy level
The rate of BT in our SAP-induced acute lung injury (SAPALI) rat model was 40%, which was similar to the previous report [28]
Summary
Severe acute pancreatitis (SAP) is a dangerous acute abdominal disease, which can cause systemic inflammatory response and rapidly accumulate multiple organs. Acute lung injury (ALI) is the most common and earliest organ with dysfunction in SAP. The mortality rate is over 30%, and the mortality rate of elderly patients is higher [1, 2]. It is one of the main causes of death in early SAP patients [3,4,5]. The research direction of SAP-induced acute lung injury (SAPALI) is mainly focused on inflammatory factor-mediated lung injury [6, 7]. Its complex pathological mechanism is not fully understood [8, 9], which leads to high mortality and huge economic burden [1, 10]
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