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Abstract
Abstract Fluids from Listeria monocytogenes cultures contain products that possess a number of biologic activities. The fluids contain a mitogenic substance for B lymphocytes. Thus, their injection into mice produces striking hyperplasia of the B cell zones of the spleen. Also, lymphocytes in vitro are stimulated to proliferate, regardless of whether they are first depleted of T lymphocytes by exposure to anti-θ serum plus complement. These fluids injected intraperitoneally activate macrophages as judged by morphologic criteria. Mice that receive the products develop a transitory state of nonspecific resistance to infection by live Listeria. The relationships between B cell mitogenicity and macrophage activation—and protection—were not established. This kind of reaction of lymphoid cells to Listeria products may represent an early nonspecific line of defense against bacterial invasion.
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