Abstract

The effects of atropine treatment on the rat's submaxillary gland were studied and compared with those of surgical parasympathetic denervation. In one day both procedures increase the weight of the gland. This gain in size of the gland is likely to be due to the secretory inactivity. In one week the effects of atropine and of surgical denervation on gland weight differ from one another. The gland weight is decreased after nerve section but not after atropine. In other respects the longterm action of atropine is similar to that of parasympathetic denervation: both procedures cause a supersensitivity to secretory agents and a decreased activity of respiratory enzymes.

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